Supplementation with low molecular weight peptides from fish protein hydrolysate reduces acute mild stress-induced corticosterone secretion and modulates stress responsive gene expression in mice

First evidence started to demonstrate the anxiolytic effects of low molecular weight peptides extracted from natural products, such as fish hydrolysate, but their underlying mechanisms remain be elucidated. The objective this study was evaluate effect a chronic administration hydrolysate on stress reactivity and understand involved. Stress response (corticosterone secretion, expression stress-responsive genes) measured in Balb/c mice supplemented with (300 mg/kg body weight) or vehicle daily for 7 days before being submitted an acute mild protocol. Our results demonstrated that 30 min after induction, decreased corticosterone level compared control mice. Moreover, supplementation modulated responsive genes involved hypothalamic pituitary adrenal axis regulation, circadian rhythm aging process. These findings suggest represents innovative strategy prevent stress-induced aversive participate management.